1. Who we are?

The Mick Knighton Mesothelioma Research Fund aims to raise awareness, fund crucial research projects.  Improve diagnosis, treatment and care for mesothelioma sufferers plus helping to access information and support.  Each and everyone are of supreme importance to the fund. The Mick Knighton Mesothelioma Research Fund works ” under the umbrella” of the British Lung Foundation and has been established in memory of my husband. Mick was diagnosed aged 59 years in August 2000 and died on the 19th March 2001, seven months after diagnosis. Mesothelioma is a type of lung cancer affecting the lung and occasionally the abdomen caused by exposure to asbestos. Mick served in the Royal Navy as a young man when asbestos products were widely used. His character, courage and sense of humour made such an impression on all who knew him. This research fund has been set up to help others, of which there will be many.

2.What is Mesothelioma?

Mesothelioma is a type of cancer. It happens in the “mesothelium” – a thin lining in your chest and your abdomen.

  • Mesothelioma in the chest:

Your chest lining has two layers lines and lung. The inner layer lines your lung, and the outer layer lines your chest wall.

The space between the two layers contains a small amount of fluid. This lubricates the two surfaces and lets the lung and chest wall move and expand as you breathe. When a tumour grows within the chest lining, it causes it to thicken at first. Then it spreads within the space between the layers. The tumour often produces fluid, sometimes several litres.

  • Mesothelioma in the abdomen:

Your abdominal cavity ( the bit below your diaphragm) and bowel are also covered by a lining. Like your chest lining, it has two layers. The inner layer covers the organs in your abdomen ( your stomach, etc.), and the outer layer lines the wall of your abdomen.

A tumour can start within this lining. It causes the lining around the organs in your abdomen to thicken. Lots of fluid can also be produced, which causes swelling of the abdomen.

3.What are the most frequent symptoms?

Symptoms or signs of mesothelioma may not appear until 20 to 50 years (or more) after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space (pleural effusion) are often symptoms of pleural mesothelioma.

Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity). Other symptoms of Peritoneal Mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.

These symptoms may be caused by mesothelioma or by other, less serious conditions.

Mesothelioma that affects the pleura can cause these signs and symptoms:

  • Chest wall pain

  • Pleural effusion, or fluid surrounding the lung

  • Shortness of breath

  • Fatigue or anemia

  • Wheezing, hoarseness, or cough

  • Blood in the sputum (fluid) coughed up (hemoptysis)

In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread, to other parts of the body.

Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:

  • Abdominal pain

  • Ascites, or an abnormal buildup of fluid in the abdomen

  • A mass in the abdomen

  • Problems with bowel function

  • Weight loss

  • In severe cases of the disease, the following signs and symptoms may be present:

  • Blood clots in the veins, which may cause thrombophlebitis

  • Disseminated intravascular coagulation, a disorder causing severe bleeding in many body organs

  • Jaundice, or yellowing of the eyes and skin

  • Low blood sugar level

  • Pleural effusion

  • Pulmonary emboli, or blood clots in the arteries of the lungs

  • Severe ascites

A mesothelioma does not usually spread to the bone, brain, or adrenal glands. Pleural tumors are usually found only on one side of the lungs.

4.What are the medical treatments?

The prognosis for malignant mesothelioma remains disappointing, although there have been some modest improvements in prognosis from newer chemotherapies and multimodality treatments.

Treatment of malignant mesothelioma at earlier stages has a better prognosis, but cures are exceedingly rare. Clinical behavior of the malignancy is affected by several factors including the continuous mesothelial surface of the pleural cavity which favors local metastasis via exfoliated cells, invasion to underlying tissue and other organs within the pleural cavity, and the extremely long latency period between asbestos exposure and development of the disease. The histological subtype and the patient's age and health status also help predict prognosis. The epithelioid histology responds better to treatment and has a survival advantage over sarcomatoid histology.

Treatments options currently available are: control of pleural effusion, drug treatment, surgery (decortication, Pleuropneumonectomy ), Radiotherapy, Palliative Care, Cryoablation ( new approach). [Read more...]

5.How can I join the group?

If you would like to join the group, please contact Mrs Chris Knighton.  [Read more...]

 We are looking forward to seeing you!

6.How can I help?

There are many ways to help us:

  • Donate: everyone’s donation is welcome, even a small amount of money can make the difference. If you would like to help us please click here.

  • Online shop: please visit our online shop,  where you can find some products to buy and help the foundation.

  • Volunteering: we will be very grateful to everyone who wishes to volunteer. Please get in touch with us.

  • Events: organising your own event not only raises money for mesothelioma research but can also be away of celebrating the life of a loved one.

  • Spread the voice: help us to increase the awareness of the Mesothelioma’s causes and risks.

7.Why more research is needed?

  • Someone dies every five hours from mesothelioma in the UK

  • There are 33% more deaths from mesothelioma than from cervical cancer

  • There will be over a million deaths in western Europe by 2035

  • 100,000 people alive today will die with mesothelioma

8. Where my money goes?

The whole amount of money from your donations will be invested for improving the Scientific Research and for finding out an appropriate medical treatment for eradicating Mesothelioma.

Thank you for your help!

British Lung Foundation
© 2012 Mick Knighton Mesothelioma Research Fund Suffusion theme by Sayontan Sinha